Publications

P4O2 COVID-19 extension

• A Systematic Review of Chest Imaging Findings in Long COVID Patients - Somayeh Bazdar, Anastasia Kwee , Laura Houweling et al. J Pers Med. 2023 Feb 1;13(2):282. doi: 10.3390/jpm13020282.

• Precision Medicine for More Oxygen (P4O2)—Study Design and First Results of the Long COVID-19 Extension Nadia Baalbaki, Jelle M. Blankestijn, Mahmoud I. Abdel-Aziz et al. J. Pers. Med. 2023, 13(7), 1060; https://doi.org/10.3390/jpm13071060

• The effect of the urban exposome on COVID-19 health outcomes: A systematic review and meta-analysis Laura Houweling, Anke-Hilse Maitland-Van der Zee, Judith C.S. Holtjer, Somayeh Bazdar, Roel C.H. Vermeulen, George S. Downward, Lizan D. Bloemsma.  Environ Res. 2023 Oct 16:117351. doi: 10.1016/j.envres.2023.117351.

• Pulmonary function 3-6 months after acute COVID-19: A systematic review and multicentre cohort study Merel E.B. Cornelissen, Asabi Leliveld, Nadia Baalbaki, Debbie Gach, Ivo van der Lee, Esther J. Nossent, Lizan D. Bloemsma, Anke-Hilse Maitland-van der Zee Heliyon 2024 Mar 13;10(6):e27964 DOI: 10.1016/j.heliyon.2024.e27964

• Fatigue and symptom-based clusters in post COVID-19 patients: a multicentre, prospective, observational cohort study Merel EB Cornelissen, Lizan D Bloemsma, Anouk W Vaes, Nadia Baalbaki, Qichen Deng, Rosanne JHCG Beijers, Lieke CE Noij, Laura Houweling, Somayeh Bazdar, Martijn A Spruit, Anke-Hilse Maitland-van der Zee; the P4O2 Consortium J Transl Med 2024 Feb 21;22(1):191. doi: 10.1186/s12967-024-04979-1.

• Long COVID exhibits clinically distinct phenotypes at 3-6 months post-SARS-CoV-2 infection: results from the P4O2 consortium Jelle M Blankestijn, Mahmoud I Abdel-Aziz, Nadia Baalbaki, Somayeh Bazdar, Inés Beekers,  Rosanne J H C G Beijers, Lizan D Bloemsma, Merel E B Cornelissen, Debbie Gach, Laura Houweling, Sebastiaan Holverda, John J L Jacobs, Reneé Jonker, Ivo van der Lee, Paulien M A Linders, Firdaus A A Mohamed Hoesein, Lieke C E Noij, Esther J Nossent, Marianne A van de Pol, Daphne W Schaminee, Annemie M W J Schols, Lisanne T Schuurman, Brigitte Sondermeijer, J J Miranda Geelhoed, Joop P van den Bergh, Els J M Weersink, Yolanda de Wit-van Wijck, Anke H Maitland-van der Zee; P4O2 consortium BMJ Open Respir Res. 2024 Apr 24;11(1):e001907. doi: 10.1136/bmjresp-2023-001907. 

• Whole blood transcriptome in long-COVID patients reveals association with lung function and immune response Jelle M Blankestijn, Nadia Baalbaki, Somayeh Bazdar, Inés Beekers, Rosanne J H C G Beijers, Joop P van den Bergh, Lizan D Bloemsma, Merel E B Cornelissen, Tamara Dekker, Jan Willem Duitman, Laura Houweling, John J L Jacobs, Ivo van der Lee, Paulien M A Linders, Lieke C E Noij, Esther J Nossent, Marianne A van de Pol, Brigitte M Sondermeijer, J J Miranda Geelhoed, Els J M Weersink, Korneliusz Golebski, Mahmoud I Abdel-Aziz, Anke H Maitland-van der Zee; P4O2 Consortium J Allergy Clin Immunol. 2024 Sep;154(3):807-818. doi: 10.1016/j.jaci.2024.04.032.

• Hemoglobin and Its Relationship with Fatigue in Long-COVID Patients Three to Six Months after SARS-CoV-2 Infection  Somayeh Bazdar, Lizan D Bloemsma,  Nadia Baalbaki, Jelle M Blankestijn, Merel E B Cornelissen, Rosanne J H C G Beijers, Brigitte M Sondermeijer, Yolanda van Wijck, George S Downward, Anke H Maitland-van der Zee; P4O2 Consortium Biomedicines. 2024 Jun  1;12(6):1234. doi:10.3390/biomedicines12061234.

• The Progression of Symptoms in Post COVID-19 Patients: A Multicentre, Prospective, Observational Cohort Study Merel E. B. Cornelissen, Myrthe M. Haarman, Jos W. R. Twisk, Laura Houweling, Nadia Baalbaki, Brigitte Sondermeijer, Rosanne J. H. C. G. Beijers, Debbie Gach, Lizan D. Bloemsma, Anke-Hilse Maitland-van der Zee, on behalf of the P4O2 Consortium Biomedicines 2024, 12(11), 2493; https://doi.org/10.3390/biomedicines12112493

• Pharmacotherapy from Pre-COVID to Post-COVID: Longitudinal Trends and Predictive Indicators for Long COVID Symptoms  Nadia Baalbaki, Sien T. Verbeek, Harm Jan Bogaard, Jelle M. Blankestijn, Vera C. van den Brink, Merel E. B. Cornelissen, Jos W. R. Twisk, Korneliusz Golebski, Anke-Hilse Maitland-van der Zee, on behalf of the P4O2 consortium Biomedicines 2024, 12(12), 2694; https://doi.org/10.3390/biomedicines12122694

• Exploring Heterogeneity of Fecal Microbiome in Long COVID Patients at 3 to 6 Months After Infection Jelle M. Blankestijn, Nadia Baalbaki, Rosanne J. H. C. G. Beijers, Merel E. B. Cornelissen, W. Joost Wiersinga, Mahmoud I. Abdel-Aziz,  Anke H. Maitland-van der Zee,  on behalf of the P4O2 Consortium Int. J. Mol. Sci. 2025, 26, 1781; https://doi.org/10.3390/ijms26041781

• A Mixed-Methods Study Exploring the Feasibility of a Digital Combined Lifestyle Intervention for Patients With Post Covid-19 Condition Debbie Gach, Charlotte D. C. Born, Lisanne L. T. Schuurman, Frits H. M. van Osch, Joop P. van den Bergh, Sanne M. P. L. Gerards, Rik Crutzen, Annemie M. W. J. Schols, Rosanne J. H. C. G. Beijers Health Expect. 2025 Jun;28(3):e70299. doi: 10.1111/hex.70299.

• Effects of cigarette smoking on SARS-CoV-2 receptor ACE2 expression in the respiratory epithelium. Irene H Heijink, Tillie-Louise Hackett , Simon D Pouwels. J Pathol. 2021 Apr;253(4):351-354. doi: 10.1002/path.5607. Epub 2021 Jan 26.

• A data management system for precision medicine John J L Jacobs, Inés Beekers, Inge Verkouter et al. PLOS Digit Health. 2025 Jan 9;4(1):e0000464. doi: 10.1371/journal.pdig.0000464.

• Toward precision medicine: Inflammatory nasal epithelial transcriptomic profiles in long COVID. Baalbaki N, Blankestijn JM, Kazer SW et al. J Allergy Clin Immunol. 2025 Jun 5:S0091-6749(25)00618-9. doi: 10.1016/j.jaci.2025.05.023.

• The Omics Landscape of Long COVID-A Comprehensive Systematic Review to Advance Biomarker, Target and Drug Discovery. Nadia Baalbaki, Elise M A Slob, Samuel W Kazer et al. Allergy 2025 Apr;80(4):932-948. doi: 10.1111/all.16526. Epub 2025 Mar 14
  
  
  P4O2 mother project

• Identifying risk factors for COPD and adult-onset asthma: an umbrella review - Judith Holtjer, Lizan Bloemsma, Rosanne Beijers et al. - Eur Respir Rev. 2023 May 3;32(168):230009. doi: 10.1183/16000617.0009-2023.
   
• Combined Lifestyle Interventions in the Prevention and Management of Asthma and COPD: A Systematic Review - Charlotte D C Born, Rohini Bhadra, George D'Souza, Stef P J Kremers, Sucharita Sambashivaiah , Annemie M W J Schols, Rik Crutzen, Rosanne J H C G Beijers; P4O2 Consortium - 

  Nutrients. 2024 May 17;16(10):1515. doi: 10.3390/nu16101515.

• Development of a Widely Accessible, Advanced Large-Scale Microfluidic Airway-on-Chip - Brady Rae, Gwenda F Vasse , Jalal Mosayebi , Maarten van den Berge, Simon D Pouwels, Irene H Heijink - Bioengineering (Basel). 2025 Feb 13;12(2):182. doi: 10.3390/bioengineering12020182.

• Alveolar Cell Composition in Interstitial Lung Disease and the Development of a Pulmonary Progressive Fibrosing Phenotype: A Retrospective Cohort Study - Simons IA, Boerrigter BG, Hovestadt MCM, Mooij-Kalverda KA, Zhang S, Boers LS, Maitland – van der Zee AH, Nossent EJ, Duitman JW. Respir Res. 2025; 26(1):164. doi: 10.1186/s12931-025-03236-3.

• Prognostic Biomarkers for the Development of Progressive Pulmonary Fibrosis in Hypersensitivity Pneumonitis: A systematic review - Simons IA, Korevaar DA, Denswil NP, Maitland-van der Zee AH, Nossent EJ, Duitman JW. Eur Respir Rev. 2025

• Bronchiectasis is associated with lower lung function in lung cancer screening participants. Anastasia K A L Kwee , Bart Luijk , Pim A de Jong , Harry J M Groen , Joachim G J V Aerts Jean-Paul Charbonnier , Rozemarijn Vliegenthart , Firdaus A A Mohamed Hoesein. Eur Radiol 2024.;34(6):4155-4162. doi: 10.1007/s00330-023-10361-4.

• Imaging-derived biomarkers in Asthma: Current status and future perspectives. Pompe E, Kwee AK, Tejwani V, Siddharthan T, Mohamed Hoesein FA. Respir Med. 2023. 208:107130. doi: 10.1016/j.rmed.2023.107130

• Higher small pulmonary artery and vein volume on computed tomography is associated with mortality in current and former smokers. Kwee AKAL, Andrinopoulou ER, van der Veer T, Gallardo-Estrella L, Charbonnier JP, Humphries SM, Lynch DA, Tiddens HAWM,
  de Jong PA, Pompe E. E BioMedicine. 2024 Oct;108:105366.  doi: 10.1016/j.ebiom.2024.105366.