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Work packages P4O2

Work package 1
Defining populations risk for respiratory disease in the Netherlands, combining risk factors and the external exposome.
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Work package 2
Identifying gene candidates and pathways involved in aberrant damage and repair responses to cigarette smoking in existing cohorts.
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Work package 3
Setting up novel 3D lab-on-a-chip culture models for tissue damage and repair.
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Work package 4
Building the PRIL(Persons at high RIsk for Lung disease)-cohort for detection of early lung damage.
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Work package 5
Analyzing the exposome in the PRIL cohort.
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Work package 6
Multi-omics in the PRIL cohort for the detection of biomarkers and potential treatable targets of sub-clinical lung disease.
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Work package 7
Imaging of the lungs, extra-pulmonary tissue and body composition in the PRIL cohort.
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Work package 8
Combining exposome, multiomics, and imaging data using artificial intelligence to identify phenotypes of groups at-risk for developing lung diseases.
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Work package 9
Personalized life style interventions and modulation of the metabolic milieu in the PRIL cohort.
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Work package 10
Mechanistic studies using advanced models to investigate how lung repair defects drive lung disease and are influenced by extra-pulmonary tissue.
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Work package 11
Local and systemic intervention studies to stimulate lung repair and prevent disease.
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Work package 12
Initiatives to involve stakeholders and disseminate findings.
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Linking of work packages in P4O2

 

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