Work packages P4O2
Work package 1
Defining populations risk for respiratory disease in the Netherlands, combining risk factors and the external exposome.
Work package 2
Identifying gene candidates and pathways involved in aberrant damage and repair responses to cigarette smoking in existing cohorts.
Work package 3
Setting up novel 3D lab-on-a-chip culture models for tissue damage and repair.
Work package 4
Building the PRIL(Persons at high RIsk for Lung disease)-cohort for detection of early lung damage.
Work package 5
Analyzing the exposome in the PRIL cohort.
Work package 6
Multi-omics in the PRIL cohort for the detection of biomarkers and potential treatable targets of sub-clinical lung disease.
Work package 7
Imaging of the lungs, extra-pulmonary tissue and body composition in the PRIL cohort.
Work package 8
Combining exposome, multiomics, and imaging data using artificial intelligence to identify phenotypes of groups at-risk for developing lung diseases.
Work package 9
Personalized life style interventions and modulation of the metabolic milieu in the PRIL cohort.
Work package 10
Mechanistic studies using advanced models to investigate how lung repair defects drive lung disease and are influenced by extra-pulmonary tissue.
Work package 11
Local and systemic intervention studies to stimulate lung repair and prevent disease.
Work package 12
Initiatives to involve stakeholders and disseminate findings.