Work packages P4O2

Defining populations risk for respiratory disease in the Netherlands, combining risk factors and the external exposome.

Identifying gene candidates and pathways involved in aberrant damage and repair responses to cigarette smoking in existing cohorts.

Setting up novel 3D lab-on-a-chip culture models for tissue damage and repair.

Building the PARASOL (Prevention of And Risk fActorS for chronic diseases: an Observational study in North HoLland)-cohort for detection of early lung damage.

Analyzing the exposome in the PRIL cohort.

Multi-omics in the PRIL cohort for the detection of biomarkers and potential treatable targets of sub-clinical lung disease.

Imaging of the lungs, extra-pulmonary tissue and body composition in the PRIL cohort.

Combining exposome, multiomics, and imaging data using artificial intelligence to identify phenotypes of groups at-risk for developing lung diseases.

Personalized life style interventions and modulation of the metabolic milieu in the PRIL cohort.

Mechanistic studies using advanced models to investigate how lung repair defects drive lung disease and are influenced by extra-pulmonary tissue.

Local and systemic intervention studies to stimulate lung repair and prevent disease.

Initiatives to involve stakeholders and disseminate findings.