HomeWork packages and cohortsCOVID extension of P4O2

COVID extension of P4O2

Many patients who have had COVID-19 continue to have health complaints for a long period of time. The long-term effects of the damage caused by the virus and the body's response to it is unclear. A team of researchers, private parties and patient representatives will investigate how these complaints develop and which factors can predict them in future patients. The project is co-funded by the PPP Allowance made available by Top Sector Life Sciences & Health (Health~Holland).

State-of-the-art measurements in post-corona clinics

Patients who have been admitted to hospital because of COVID-19 and those who consulted their GP after remaining ill for a long time after COVID-19, were referred to a post-corona clinic where lung function tests, CT scans, questionnaires, and laboratory tests were be performed. For this P4O2-COVID study, additional tests were performed in middle-aged patients when they visit the clinic approximately 3 and 12 months after their initial infection.

State-of-the-art measurements and analyzes that are applied within renowned scientific studies were performed in the 95 people participating in this study. For example, additional biological samples were taken to perform various –omics measurements (a method to very extensively map biological and chemical process, for example, gene regulation, metabolism, or bacteria in the body) to gain insight into possible differences in the biological response of patients with long-term complaints. The exposome of these patients will also be mapped. These are environmental and social factors which people experience in daily life, such as chemicals, air pollution, smoking, dietary intake, and physical activity. Participants  received devices that measured their exposure and physical activity, for example a bracelet that collects substances from the environment. CT scans will be analyzed using the latest artificial intelligence methods. Participants were also offered an intervention focused on nutrition and physical activity that was expected to have a beneficial effect on quality of life. Furthermore, with the help of experimental cell models, laboratory research will help to identify factors and mechanisms that predict a more serious course of disease. Using big-data analysis, a pattern will be sought in the data that predicts who is susceptible to developing chronic complaints after the disease in future patients.

This research fits the missions of the Top Sector LSH, as there is attention for unhealthy lifestyle and the living environment (mission I) and for care provided to people within their own living environment (mission II). The P4O2-COVID study will reduce the proportion of people with a chronic disease or lifelong disability (mission III).

Current state
In August 2022 we stopped inclusion for new patients. In June 2023 we will see the last patient for the second study visit 9 months after the first visit (12-15 months after the infection). The  exposome home visits are finished and the data is being analysed at the moment. The nutrition and physical activity intervention is followed completed by 38 persons and is still running in others. The first biological samples are being analysed at the moment. Soon the data will also be shared with the imaging partners, so they can perform their analyses of the CT scans. 

About the consortium

The P4O2-COVID study will be performed by partners from the P4O2 consortium; this consortium originated from the National Program for Lung Research, which the Netherlands Respiratory Society (NRS) developed together with other lung associations, researchers, healthcare professionals, patients, and companies to generate more attention for lung diseases and to improve cooperation between lung researchers in the Netherlands. Collaboration with industry will promote implementation of the acquired knowledge.

Partners and sponsors of the P4O2 COVID project are Amsterdam UMC, LUMC, UMCG, UMC Utrecht, Utrecht University, Maastricht University and Maastricht UMC+, Boehringer Ingelheim, Breathomix, Fluidda, Novartis, Ortec Logiqcare, Philips, Quantib-U, Smartfish, SODAQ, Thirona, and TopMD. The collaboration project is co-funded by the PPP Allowance made available by Health~Holland, Top Sector Life Sciences & Health, to stimulate public-private partnerships (https://www.health-holland.com). The consortium is led by Prof. Dr. Anke-Hilse Maitland - van der Zee from the Amsterdam UMC, location AMC. More information is available via nrs@nrs-science.nl

Photo by Thijs Rooimans

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